TMSBr/InBr3-promoted Prins cyclization/homobromination of dienyl alcohol with aldehyde to construct cis-THP containing an exocyclic E-alkene.
نویسندگان
چکیده
A TMSBr/InBr3-promoted Prins cyclization/homobromination reaction of dienyl alcohol with aldehyde has been developed to construct a unique cis-E THP shown as the A ring in (-)-exiguolide and the B ring in bryostatins.
منابع مشابه
Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions.
Prins cyclization between a homoallylic alcohol and an aldehyde, promoted by trimethylsilyl halide, afforded 4-halo-tetrahydropyrans with good to excellent yields. Thanks to the absence of the solvent and metal, the THP thus obtained have been implicated without purification in several other reactions, in a sequential way, affording in particular new indole derivatives.
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عنوان ژورنال:
- Chemical communications
دوره 51 80 شماره
صفحات -
تاریخ انتشار 2015